Molecular Biology Lab

 

                                               School of Biotechnology & Biomedical Science

                                                     Inje University, Gimhae 621-749,  Korea

 Biology2      Biology and human     Mol Bio Diseases   Functional Genomics     Mol Cell Biol     Graduate Lecture    Physiology  

 

Gene manipulation exp 

   

 

 

학력

1963~1969 단계초등학교(경남 산청군 신등면)
1969~1972 신등중학교(경남 산청군 신등면)

1972~1975 진주고등학교

1975~1979 서울대학교 미생물학과 학사

1981~1983 서울대학교 미생물학과 석사

1984~1988  영남대학교 생물학과 박사


경력 

1979~1981 육군제3사관학교 생물학 강사
1983~1984 서울대학교 의과대학 내분비학교실 연구원
1984~1988 영남대학교 의과대학 생화학교실 연구원
1988~1991 University of Wyoming 연구원
1991~1992 University of Wyoming 조교수
1992~1993 서울대학교 분자미생물연구센터 연구원
2002~2003 University of Kentucky  교환교수
2012~2013 University of Illinois, Urbana-Champaign  교환교수
1993~현재   인제대학교 의생명공학과 교수

                

연구논문
1. Sohn J., Youn H., Jeoung M., Koo, Y., Yi, C., Ji, I., and  Ji, TH.(2003) Orientation of follicle-stimulating hormone (FSH) subunits complexed with the FSH receptor. Beta subunit toward the N terminus of exodomain and alpha subunit to exoloop 3 J. Biol. Chem. 278(48):47868-76 [Abstract] [Full Text]

2. Ji,I Lee, C., Jeoung, M., Koo, Y., Sievert, G.A., and Ji, T.H. (2004) Trans-activation of mutant FSH receptors selectively generates only one of two hormone signals. Mol.Endocrinol.18(4): 968-978  [Abstract]

3. Youn, H., Koo, Y., Ji, I and Ji, T.H. (2005) An upstream initiator-like element suppresses transcription of the rat luteinizing hormone receptor gene. Mol. Endocrinol. 19(5): 1318-1328 [Abstract]

4. Mary C. Gieske, GiYoun Na, Yongbum Koo, Misung Jo, Thomas E. Curry Jr., and Chemyong Ko (2005) Decay-Accelerating Factor (DAF) in the Periovulatory Rat Ovary. J. Endocrinol: 186:303-313[Abstract]

5. CheMyong Ko, Mary C. Gieske, Linah Al-Alem, YunKyung Hahn, Wen Su, Ming C. Gong, Marc Iglarz, and Yongbum Koo (2006) Endotheiln-2 in Ovarian Follicle Rupture. Endocrinology 474: 1770-1779 [Abstract]
6. bHyeSook Youn, MyoungKun Jeoung, YongBum Koo, Hanlee Ji, William R. Markesbery, Inhae Ji, Tae H. Ji (2007) Kalirin is under-expressed in Alzheimer's Disease Hippocampus. J. Alzheimer's disease 11: 385-397[Abstract][Full text]
7. Park, J., Kim, M., Jeon, I., Kwon, Y-k, Kim, J-h., Youn, H., and Koo, Y. (2007) Glucocorticoids modulate NF-kB-dependent gene expression by up-regulating FKBP51 expression in NDV-infected chickens. Mol. Cell. Endocrinol. 278: 7-17 [Abstract][Full text]
8. Gieske MC, Kim HJ, Legan SJ, Koo Y, Krust A, Chambon P, Ko C. (2008) Pituitary gonadotroph estrogen receptor alpha (ER{alpha}) is necessary for fertility in females. Endocrinol. 149: 20-27 [Abstract]

9. Na G, Bridges PJ, Koo Y, Ko C. (2008) Role of hypoxia in the regulation of periovulatory EDN2 expression in the mouse. Can J Physiol Pharmacol. 2008 ;86:310-9.[Abstract]

10. Phillip J. Bridges , Yongbum Koo , Dong-Wook Kang , Susan Hudgins-Spivey , Zi-Jian Lan , Xueping Xu , Francesco DeMayo , Austin Cooney , CheMyong Ko. (2008) Generation of Cyp17iCre transgenic mice and their application to conditionally delete estrogen receptor alpha (Esr1) from the ovary and testis. Genesis 46:499-505 [Abstract]

11. Sungeun Lee, Dong-Wook Kang, Susan Hudgins-Spivey, Andree Krust, Eun-Young Lee, Youngbum Koo, Yongpil Cheon, Myung Chan Gye, Pierre Chambon, and CheMyong Ko. (2009) Theca-Specific Estrogen Receptor-α Knockout Mice Lose Fertility Prematurely. Endocrinology 150(8): 3855–3862.

12. Sang-Im Yun, Byung-Hak Song, Yongbum Koo, Iksoo Jeon, Sung June Byun, Jong-Hyeon Park, Yi-Seok Joo, Seok-Yong Kim, Young-Min Lee(2009) Japanese encephalitis virus-based replicon RNAs/particles as an expression system for HIV-1 Pr55Gag that is capable of producing virus-like particles.  Virus Research 144: 298-305

 
13.나기윤, 이영민, 변승준, 전익수, 박종현, 조인수, 주이석, 이윤정, 권준헌, 구용범 (2009) 배양세포에서 Semi-quantitative RT-PCR에 의한 조류인플루엔자 H9N2의 전사활성 분석 최적 시기 결정 및 전사체 분석. 미생물학회지 45: 286-290

 
14. Na G, Wolfe A, Ko C, Youn H, Lee YM, Byun SJ, Jeon I, Koo Y. (2013) A low-copy-number plasmid for retrieval of toxic genes from BACs and generation of conditional targeting constructs.Mol Biotechnol. 54(2):504-14

15 Novaira HJ, Sonko ML, Hoffman G, Koo Y, Ko C, Wolfe A, Radovick S. (2014) Disrupted kisspeptin signaling in GnRH neurons leads to hypogonadotrophic hypogonadism. 28(2):225-38

16. Cacciopo JA, Koo Y, Lin PP, Gal A, Ko C(2015) Generation and characterization of an endothelin-2 iCre mouse. Genesis 53(2) 245~256

17. Cacciopo JA, Koo Y, Lin PP, Osmulski SA, Ko CD, Ko C (2016) Generation of estrogen receptor beta-iCre knock-in mouse. Genesis 54(1) 38~52

18. Park CJ, Chen G, Koo Y, Lin PP, Cacciopo JA, Prohaska H, Ko C (2017) Generation and characterization of an estrogen alpha-iCre knock-in mouse. Genesis 55(12)