Molecular Biology Lab


                                               School of Biotechnology & Biomedical Science

                                                     Inje University, Gimhae 621-749,  Korea

 Biology2      Biology and human     Mol Bio Diseases   Functional Genomics     Mol Cell Biol     Graduate Lecture    Physiology  


Gene manipulation exp 




Main research area



Control of avian influenza at molecular levels.


Signal to gene expression by steroid hormones.




 Recent publications


Sohn J., Youn H., Jeoung M., Koo, Y., Yi, C., Ji, I., and  Ji, TH.(2003) Orientation of follicle-stimulating hormone (FSH) subunits complexed with the FSH receptor. Beta subunit toward the N terminus of exodomain and alpha subunit to exoloop 3 J. Biol. Chem. 278(48):47868-76 [Abstract] [Full Text]

Ji,I Lee, C., Jeoung, M., Koo, Y., Sievert, G.A., and Ji, T.H. (2004) Trans-activation of mutant FSH receptors selectively generates only one of two hormone signals. Mol.Endocrinol.18(4): 968-978  [Abstract]

Youn, H., Koo, Y., Ji, I and Ji, T.H. (2005) An upstream initiator-like element suppresses transcription of the rat luteinizing hormone receptor gene. Mol. Endocrinol. 19(5): 1318-1328 [Abstract]

Mary C. Gieske, GiYoun Na, Yongbum Koo, Misung Jo, Thomas E. Curry Jr., and Chemyong Ko (2005) Decay-Accelerating Factor (DAF) in the Periovulatory Rat Ovary. J. Endocrinol: 186:303-313[Abstract]

CheMyong Ko, Mary C. Gieske, Linah Al-Alem, YunKyung Hahn, Wen Su, Ming C. Gong, Marc Iglarz, and Yongbum Koo (2006) Endotheiln-2 in Ovarian Follicle Rupture. Endocrinology 474: 1770-1779 [Abstract]
HyeSook Youn, MyoungKun Jeoung, YongBum Koo, Hanlee Ji, William R. Markesbery, Inhae Ji, Tae H. Ji (2007) Kalirin is under-expressed in Alzheimer's Disease Hippocampus. J. Alzheimer's disease 11: 385-397[Abstract][Full text]
Park, J., Kim, M., Jeon, I., Kwon, Y-k, Kim, J-h., Youn, H., and Koo, Y. (2007) Glucocorticoids modulate NF-kB-dependent gene expression by up-regulating FKBP51 expression in NDV-infected chickens. Mol. Cell. Endocrinol. 278: 7-17 [Abstract][Full text]
Gieske MC, Kim HJ, Legan SJ, Koo Y, Krust A, Chambon P, Ko C. (2008) Pituitary gonadotroph estrogen receptor alpha (ER{alpha}) is necessary for fertility in females. Endocrinol. 149: 20-27 [Abstract]


Na G, Bridges PJ, Koo Y, Ko C. (2008) Role of hypoxia in the regulation of periovulatory EDN2 expression in the mouse. Can J Physiol Pharmacol. 2008 ;86:310-9.[Abstract]


Phillip J. Bridges , Yongbum Koo , Dong-Wook Kang , Susan Hudgins-Spivey , Zi-Jian Lan , Xueping Xu , Francesco DeMayo , Austin Cooney , CheMyong Ko. (2008) Generation of Cyp17iCre transgenic mice and their application to conditionally delete estrogen receptor alpha (Esr1) from the ovary and testis. Genesis 46:499-505 [Abstract]


Sungeun Lee, Dong-Wook Kang, Susan Hudgins-Spivey, Andree Krust, Eun-Young Lee, Youngbum Koo, Yongpil Cheon, Myung Chan Gye, Pierre Chambon, and CheMyong Ko. (2009) Theca-Specific Estrogen Receptor-α Knockout Mice Lose Fertility Prematurely. Endocrinology 150(8): 3855–3862.


Sang-Im Yun, Byung-Hak Song, Yongbum Koo, Iksoo Jeon, Sung June Byun, Jong-Hyeon Park, Yi-Seok Joo, Seok-Yong Kim, Young-Min Lee(2009) Japanese encephalitis virus-based replicon RNAs/particles as an expression system for HIV-1 Pr55Gag that is capable of producing virus-like particles.  Virus Research 144: 298-305


나기윤, 이영민, 변승준, 전익수, 박종현, 조인수, 주이석, 이윤정, 권준헌, 구용범 (2009) 배양세포에서 Semi-quantitative RT-PCR에 의한 조류인플루엔자 H9N2의 전사활성 분석 최적 시기 결정 및 전사체 분석. 미생물학회지 45: 286-290


Na G, Wolfe A, Ko C, Youn H, Lee YM, Byun SJ, Jeon I, Koo Y. (2013) A low-copy-number plasmid for retrieval of toxic genes from BACs and generation of conditional targeting constructs.Mol Biotechnol. 54(2):504-14


Novaira HJ, Sonko ML, Hoffman G, Koo Y, Ko C, Wolfe A, Radovick S. (2014) Disrupted kisspeptin signaling in GnRH neurons leads to hypogonadotrophic hypogonadism. 28(2):225-38