Publications

     58. Hye-Lim Kim, Hyun-Chul Ryu, Young Shik Park (2017) Quantitative analysis by flow cytometry of green fluorescent protein-tagged human phenylalanine hydroxylase expressed in Dictyostelium . Pteridines 28, 153-156.

     57. Hye-Lim Kim, Hyun-Chul Ryu, Young Shik Park (2017) Investigation of a potential role for aldose reductase AlrA in tetrahydropteridine synthesis in Dictyostelium discoideum Ax2. Pteridines 28, 97-103.

     56. Asaithambi Killivalavan, Young Shik Park, Kon Ho Lee (2017) Pteridine glycosyltransferase from Chlorobium tepidum: crystallization and X-ray analysis. Acta Cryst. F73, 629-634.

     55. Yu-Min Kim, Yun Gyeong Yang, Hye-Lim Kim, Young Shik Park (2015) Dictyostelium discoideum Ax2 as an assay system for screening of pharmacological chaperones for phenylketonuria mutations. J Microbiol. Biotechnol. 25(6), 782-787.

     54. Seo KH, Zhuang N, Park YS, Park KH, Lee KH. (2014) Structural basis of a novel activity of bacterial 6-pyruvoyltetrahydropterin synthase homologues distinct from mammalian 6-pyruvoyltetrahydropterin synthase activity. Acta Crystallogr D Biol Crystallogr. May;70(Pt 5):1212-23.

     53. Asaithambi Killivalavan, Ningning Zhuang, Young Shik Park and Kon Ho Lee (2014) Purification, crystallization and preliminary X-ray diffraction studies of UDP-glucose: tetrahydrobiopterin a-glucosyltransferase (BGluT) from Synechococcus sp. PCC 7942. Acta Crystallographica Section F. 70, 203–205.

     52. Won Ki Hong, Kwang Yong Shim, Soon Koo Baik, Moon Young Kim, Mee Yon Cho, Yoon Ok Jang,Young Shik Park, Jin Han, Gaeun Kim, Youn Zoo Cho, Hye Won Hwang, Jin Hyung Lee, Myeong Hun Chae, and Sang Ok Kwon (2014) Relationship between Tetrahydrobiopterin and Portal Hypertension in Patients with Chronic Liver Disease. J Korean Med Sci. 29: 392-399.

      51. Seon-Ok Park, Hye-Lim Kim, Soo-Woong Lee, and Young Shik Park (2013) Tetrahydropteridines possess antioxidant roles to guard against glucose-induced oxidative stress in Dictyostelium discoideum. BMB Reports.46(2):86-91.

      50. Hye-Lim Kim, Mi Bi Park, Soo-Woong Lee, and Young Shik Park (2013) Altered sugar donor specificity and catalytic activity of pteridine glycosyltransferases by domain swapping or site-directed mutagenesis. BMB Reports. 46(1):37-40.

      49. Kim HL, Park MB, Park YS. (2012) Dictyostelium phenylalanine hydroxylase is activated by its substrate phenylalanine. FEBS Lett. 586:3596-3600.

      48. Kim HL, Park MB, Park YS. (2011) Tetrahydrobiopterin is functionally distinguishable from tetrahydrodictyopterin in Dictyostelium discoideum Ax2. FEBS Lett. 585(19):3047-51.

      47. Chen C, Kim HL, Zhuang N, Seo KH, Park KH, Han CD, Park YS, Lee KH. (2011) Structural insights into the dual substrate specificities of mammalian and Dictyostelium dihydropteridine reductases toward two stereoisomers of quinonoid dihydrobiopterin. FEBS Lett. 585(17):2640-6.

      46.  Hye-Lim Kim and Young Shik Park (2010) Maintenance of tetrahydrobiopterin homeostasis. BMB Reports. 43: 584-592.

      45.  Yeol Gyun Lee, Ae Hyun Kim, Mi Bi Park, Hye-Lim Kim, Kon Ho Lee, and Young Shik Park (2010) Molecular cloning of cyanobacteria pteridine glycosyltransferases that catalyze either glucose or xylose transfer to tetrahydrobiopterin. 76:7658-61.

      44.  Moon Yoon-Jung; Lee Eun-Mi; Park Young Mok; Park Young Shik; Chung Won-Il; Chung Young-Ho (2010) The role of cyanopterin in UV/blue light signal transduction of Cyanobacterium Synechocystis sp. PCC 6803 phototaxis. Plant & cell physiology 51(6):969-80.

      43.  Zhuang Ningning; Seo Kyung Hey; Chen Cong; Kim Hye Lim; Park Young Shik; Lee Kon Ho (2010) Purification, crystallization and crystallographic analysis of Dictyostelium discoideum phenylalanine hydroxylase in complex with dihydrobiopterin and FeIII. Acta crystallographica. Section F, 66(Pt 4):463-6.

      42.  Kim Hye-Lim; Kim Do Hyung; Lee Yeol Kun; Park Sun Ok; Lee Yong-Woo; Kwon O-Seob; Park Young Shik (2010). An enzymatic method to distinguish tetrahydrobiopterin from oxidized biopterins using UDP-glucose:tetrahydrobiopterin glucosyltransferase. Analytical biochemistry 397(1):79-83.

      41.  Lee Chang-Kwon; Han Jin Soo; Won Kyung-Jong; Jung Seung-Hyo; Park Hyo-Jun; Lee Hwan Myung; Kim Junghwan; Park Young Shik; Kim Hyun-Jung; Park Pyo-Jam; Park Tae-Kyu; Kim Bokyung (2009). Diminished expression of dihydropteridine reductase is a potent biomarker for hypertensive vessels. Proteomics 9(21):4851-8.

      40.  Chen Cong; Seo Kyung Hye; Kim Hye Lim; Zhuang Ningning; Park Young Shik; Lee Kon Ho (2008). Crystallization and preliminary characterization of dihydropteridine reductase from Dictyostelium discoideum. Acta crystallographica. Section F, Structural biology and crystallization communications 64(Pt 11):1013-5.

      39. Supangat Supangat; Park Sun Ok; Seo Kyung Hye; Lee Sang Yeol; Park Young Shik; Lee Kon Ho (2008) Role of Phe-99 and Trp-196 of sepiapterin reductase from Chlorobium tepidum in the production of L-threo-tetrahydrobiopterin. Acta biochimica et biophysica Sinica 40(6):513-8.

      38. Yong Kee Choi, Jin Sun Kong, Young Shik Park (2006) Functional role of sepiapterin reductase in the biosynthesis of tetrahydropteridines in Dictyostelium discoideum Ax2. Biochim. Biophys. Acta 1760, 877-882

      37. Seo Kyung Hye; Supangat; Kim Hye Lim; Park Young Shik; Jeon Che Ok; Lee Kon Ho. Purification, crystallization and preliminary crystallographic analysis of a 6-pyruvoyltetrahydropterin synthase homologue from Esherichia coli.

      36. Hye-Lim Kim, Yong Kee Choi, Do Hyung Kim, Sun Ok Park, Jin Han, Young Shik Park (2007) Tetrahydropteridine deficiency impairs mitochondrial function in Dictyostelium discoideum Ax2.  FEBS Letters 581, 5430–5434

      35. Taylor Moran-Gates, Christopher Grady, Young Shik Park, Ross J. Baldessarini, Frank I. Tarazi (2007) Effects of risperidone on dopamine receptor subtypes in developing rat brain. European Neuropsychopharmacology 17, 448–455

      34. Kong JS, Kang JY, Kim HL, Kwon OS, Lee KH, Park YS (2006) 6-Pyruvoyltetrahydropterin synthase orthologs of either a single or dual domain structure are responsible for tetrahydrobiopterin synthesis in bacteria. FEBS Lett. 580: 4900-4

      33. Seungkyong Yang, Young Jae Lee, Jin-Man Kim, Sean Park, Joanna Peris, Philip Laipis, Young Shik Park, Jae Hoon Chung, and S. Paul Oh (2006) A murine model for human sepiapterin-reductase deficiency. Am. J. Human Genetics 78, 575-587

      32. Taylor Moran-Gates, Lu Gan, Young-Shik Park, Kehong Zhang, Ross J. Baldessarini, Frank I. Tarazi (2006) Effects of repeated antipsychotic drug treatment and withdrawal on dopamine receptor subtypes in developing rats. Synapse 59(2) 92-100.

      31. Supangat Supangat, Kyung Hye Seo, Yong Kee Choi, Young Shik Park, Daeyoung Son, Chang-deok Han, and Kon Ho Lee (2006) Structure of Chlorobium tepidum sepiapterin reductase complex reveals the novel substrate binding mode for stereospecific production of L-threo-tetrahydrobiopterin. J. Biol. Chem. 281(4), 2249-2256

      30. Yong Kee Choi, Jung Soon Park, Jin Seon Kong, Takahiro Morio, Young Shik Park  (2005) D-threo-tetrahydrobiopterin is synthesized via 1’-oxo-2'-D-hydroxy-tetrahydropterin in Dictyostelium discoideum Ax2. FEBS Lett. 579, 3085-3089.

      29. En-Young Cha, Jeong Soon Park, Sireong Jeon, Jin Seon Kong, Yong Kee Choi, Jee-Youn Ryu, Youn-Il Park, Young Shik Park (2005) Functional Characterization of the Gene Encoding UDP-glucose: tetrahydrobiopterin α-glucosyltransferase in Synechococcus sp. PCC 7942. J. Microbiol. 43(2), 191-195.

      28. S Supangat, YK Choi, YS Park, D Son, C Han, KH Lee (2005) Expression, purification, crystallization and preliminary X-ray analysis of sepiapterin reductase from Chlorobium tepidum. Acta Cryst. F61, 202-204.

      27. YK Choi, S Jun, E Cha, JS Park, YS Park (2005) Sepiapterin reductases from Chlorobium tepidum and Chlorobium limicola catalyze the synthesis of L-threo-tetrahydrobiopterin from 6-pyruvoyltetrahydropterin. FEMS Microbiol. Lett. 242, 95–99.

      26. HJ Woo, YK Hwang, YJ Kim, JY Kang, YK Choi, CG Kim, YS Park (2002) Escherichia coli 6-pyruvoyltetrahydropterin synthase ortholog has a new catalytic activity to convert sepiapterin to dihydropterin. FEBS Lett. 523, 234-8.

      25. HJ Woo, JY Kang, YK Choi, YS Park (2002) Production of sepiapterin in Escherichia coli by coexpression of cyanobacterial GTP cyclohydrolase I and human 6-pyruvoyltetrahydropterin synthase. Appl. Environ. Microbiol. 68(6), 3138-3140.

      24. YK Hwang, JY Kang, HJ Woo, YK Choi, YS Park (2002) Functional investigation of a gene encoding pteridine glycosyltransferase for cyanopterin synthesis in Synechocystis sp. PCC 6803. Biochim. Biophys. Acta 1570(2), 141-144.

      23. YK Choi, YK Hwang, YS Park (2001) Molecular cloning and disruption of a novel gene encoding UDP-glucose:tetrahydrobiopterin alpha-glucosyltransferase gene in Synechococcus sp. PCC 7942. FEBS Lett. 502, 73-78.

      22. YK Choi, YK Hwang, YH Kang, YS Park (2001) Chemical structure of 1-O-(L-erythro-biopterin-2'-yl)-alpha-glucose isolated from a cyanobacterium Synechococcus sp. PCC 7942. Pteridines, 12(3), 121-125.

      21. HJ Chung, Y Kim, YJ Kim, YK Choi, YK Hwang, YS Park (2000) Purification and characterization of UDP-glucose:tetrahydrobiopterin glucosyltransferase from Synechococcus sp. PCC 7942. Biochim. Biophys. Acta 1524, 183-188. 

      20. DK Ahn, YS Park, JG Park, JS Lee, JA Lee (2000) Quantitation of DSP toxins in the mussels of the Jinhae Bay by fluorometric HPLC analysis and protein phosphatase inhibition assay. Algae 15(4), 307-314.

      19. Y Kim, HJ Chung, YJ Kim, YK Choi, YK Hwang, SW Lee, YS Park (2000) Characterization of recombinant Dictyostelium discoideum sepiapterin reductase expressed in E. coli. Mol. Cells 10, 405-410.

      18. VC Srivastava, YS Park, JA Lee (1999) Comparison of HPLC analysis and protein phosphatase assay in the detection of cyanobacterial toxins in the Naktong River samples. Algae 14(2), 111-115.

      17. JG Park, YS Park (1999) Comparison of the morphological characteristics and the 24S rRNA sequences of Cochlodinium polykrikoides and Gyrodinium impudicum. The Sea 4(4), 363-370.

      16. SW Lee, HW Lee, HJ Chung, YA Kim, YJ Kim, JH Chung, YS Park (1999) Identification of the genes encoding enzymes involved in the early biosynthetic pathway of pteridines in Synechocystis sp. PCC 6803. FEMS Microbiol. Lett.176(1), 169-176.

      15. KH Oh, CS Seong, SW Lee, OS Kwon, YS Park (1999) Isolation of psychrotrophic Azospirillum sp. and characterization of its extracellular protease. FEMS Microbiol. Lett. 174(1), 173-178.

      14. SW Lee, IY Park, Y Hahn, JE Lee, CS Seong, JH Chung, YS Park (1999) Cloning of mouse sepiapterin reductase gene and characterization of its promoter region. BBA, 1445(1), 165-171.

      13. JH Chang, S Yoon, SM Lhee, I Park, DY Jung, YS Park, J Yim (1999) Purification and properties of novel calcium-binding proteins from Streptomyces coelicolor. J. Microbiol. 37(1), 21-26.

      12. HW Lee, CH Oh, A Geyer, W Pfleiderer, YS Park (1999) Characterization of a novel unconjugated pteridine glycoside, cyanopterin, in Synechocystis sp. PCC 6803. BBA 1410, 61-70.

      11. CS Seong, YA Kim, HJ Chung, S park, J Yim, K Baek, YS Park, K Han, J Yoon (1998) Isolation and characterization of the Drosophila melanogaster cDNA encoding the sepiapterin reductase. BBA 1443, 239-244.

      10. SW Lee, YS Park (1998) Biosynthesis of tetrahydrobiopterin in an aquatic fungus, Allomyces macrogynus. Kor. J. Microbiol. 34(4), 243-247.

      9. SW Lee, HW Lee, JG Park, JA Lee, YS Park (1998) Molecular phylogeny of phytoplankton isolated from red tides in southern coast of Korea. The Sea 3(2), 90-93.

      8. YS Park, CS Seoung, SW Lee, KH Lee, DH Lee, J Yim (1998) Identification of three novel mutations in Korean phenylketonuria patients: R53H, N207D, and Y325X. Human Mutation S1, 121-122.

      7. J Kim, YS Park, JH Chung, L Stubbs (1997) The gene encoding sepiapterin reductase is located in central mouse Chromosome 6. Mamm. Genome 8, 942.

      6. SW Lee, JH Chung, YB Koo, YS Park (1997) Structure of the mouse sepiapterin reductase gene and characterization of its 5'-flanking region. Proc. 11th Int'l Symp. Chem. Biol. of Pteridines and Folates. pp. 639-642.

      5. SW Lee, HW Lee, YS Park (1997) Analysis of genes involved in the biosynthesis of unconjugated pteridines in microorganisms. Proc. Mol. Biol. & Genet. 12, 55-56.

      4. CS Seong, OS Kwon, YS Park (1997) Diversity of uncultured microorganisms associated with the anaerobic pentachlorophenol degradation estimated by comparative RFLP analysis of PCR-amplified 16S rDNA clones. Kor. J. Microbiol. 33(2), 149-156.

      3. YS Park, KH Oh, SW Lee, CS Seong, I Park, J Yim (1996) Stage-specific changes and regulation of endogenous protein phosphorylation in Allomyces macrogynus. J. Microbiol. 34(4), 374-378.

      2. CS Seong, SW Lee, Y Hahn, JH Chung, JA Lee, YS Park (1996) 16S rRNA gene sequence of a Microcystis sp. from cyanobacterial mat in Sonakdong river. Kor. J. Microbiol. 22(3), 205-208.

      1. YS Park, N Kim, H Kim, D Park, J Yim (1995) Expression and characterization of recombinant Drosophila 6-pyruvoyltetrahydropterin synthase. Pteridines 6, 58-62

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HJ Chung, Y Kim, YS Park (2000) Cloning and characterization of microbial sepiapterin reductases and pterin glycosyltransferases. Oral presentation in 12th International Conference on Pterins, Folates, and Related Biogenic Amines (March 18-25).  

HJ CHUNG, YS PARK (2000) Characterization of a pterin glycosyltransferase isolated from a cyanobacterium, Synechococcus sp. PCC 7942. Oral presentation in 11th Winter Conference of the Korean Society for Molecular Biology (Feb. 10-12). 

 SW Lee, HW Lee, HJ Chung, YA Kim, YJ Kim, YS Park (1998) Targeted disruption of the GTP cyclohydrolase I gene in Synechocystis sp. PCC 6803. Proc. Mol. Biol. & Genet. 13, 13-15.

YS Park (1998) Structure and function of cyanopterin in Synechocystis sp. PCC 6803. Oral presentation in 11th Sorak Conference of the Society of Korea Biochemistry and Molecular.